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Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme

Ferrochelatase (EC 4.99.1.1), the terminal enzyme of the haem biosynthetic pathway, catalyses the chelation of Fe(II) into the protoporphyrin IX ring. The energetics of the binding between murine ferrochelatase and mesoporphyrin were determined using isothermal titration calorimetry, which revealed...

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Bibliografiske detaljer
Main Authors: Franco, Ricardo, Bai, Guangyue, Prosinecki, Vesna, Abrunhosa, Filipa, Ferreira, Gloria C., Bastos, Margarida
Format: Artigo
Sprog:Inglês
Udgivet: Portland Press Ltd. 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134880/
https://ncbi.nlm.nih.gov/pubmed/15496139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040921
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