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Nickel(II) Chelatase Variants Directly Evolved from Murine Ferrochelatase: Porphyrin Distortion and Kinetic Mechanism

The heme biosynthetic pathway culminates with the ferrochelatase-catalyzed ferrous iron chelation into protoporphyrin IX to form protoheme. The catalytic mechanism of ferrochelatase has been proposed to involve the stabilization of a nonplanar porphyrin to present the pyrrole nitrogens to the metal...

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Detalhes bibliográficos
Main Authors: McIntyre, Neil R., Franco, Ricardo, Shelnutt, John A., Ferreira, Gloria C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050429/
https://ncbi.nlm.nih.gov/pubmed/21222436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101170p
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