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Nickel(II) Chelatase Variants Directly Evolved from Murine Ferrochelatase: Porphyrin Distortion and Kinetic Mechanism

The heme biosynthetic pathway culminates with the ferrochelatase-catalyzed ferrous iron chelation into protoporphyrin IX to form protoheme. The catalytic mechanism of ferrochelatase has been proposed to involve the stabilization of a nonplanar porphyrin to present the pyrrole nitrogens to the metal...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: McIntyre, Neil R., Franco, Ricardo, Shelnutt, John A., Ferreira, Gloria C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3050429/
https://ncbi.nlm.nih.gov/pubmed/21222436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101170p
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