Substitution of murine ferrochelatase glutamate-287 with glutamine or alanine leads to porphyrin substrate-bound variants.

Ferrochelatase (EC 4.99.1.1) is the terminal enzyme of the haem biosynthetic pathway and catalyses iron chelation into the protoporphyrin IX ring. Glutamate-287 (E287) of murine mature ferrochelatase is a conserved residue in all known sequences of ferrochelatase, is present at the active site of th...

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Autores principales: Franco, R, Pereira, A S, Tavares, P, Mangravita, A, Barber, M J, Moura, I, Ferreira, G C
Formato: Artigo
Lenguaje:Inglês
Publicado: 2001
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221830/
https://ncbi.nlm.nih.gov/pubmed/11336654
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