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Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme

Ferrochelatase (EC 4.99.1.1), the terminal enzyme of the haem biosynthetic pathway, catalyses the chelation of Fe(II) into the protoporphyrin IX ring. The energetics of the binding between murine ferrochelatase and mesoporphyrin were determined using isothermal titration calorimetry, which revealed...

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Autori principali: Franco, Ricardo, Bai, Guangyue, Prosinecki, Vesna, Abrunhosa, Filipa, Ferreira, Gloria C., Bastos, Margarida
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134880/
https://ncbi.nlm.nih.gov/pubmed/15496139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040921
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