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Porphyrin-substrate binding to murine ferrochelatase: effect on the thermal stability of the enzyme

Ferrochelatase (EC 4.99.1.1), the terminal enzyme of the haem biosynthetic pathway, catalyses the chelation of Fe(II) into the protoporphyrin IX ring. The energetics of the binding between murine ferrochelatase and mesoporphyrin were determined using isothermal titration calorimetry, which revealed...

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Détails bibliographiques
Auteurs principaux: Franco, Ricardo, Bai, Guangyue, Prosinecki, Vesna, Abrunhosa, Filipa, Ferreira, Gloria C., Bastos, Margarida
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2005
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134880/
https://ncbi.nlm.nih.gov/pubmed/15496139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040921
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