BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II

Mammalian cells exhibit a complex response to DNA damage. The tumor suppressor BRCA1 and associated protein BARD1 are thought to play an important role in this response, and our previous work demonstrated that this includes transient inhibition of the pre-mRNA 3′ processing machinery. Here we provid...

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Hlavní autoři: Kleiman, Frida E., Wu-Baer, Foon, Fonseca, Danae, Kaneko, Syuzo, Baer, Richard, Manley, James L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2005
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1132008/
https://ncbi.nlm.nih.gov/pubmed/15905410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1309505
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