A Single Nucleotide Change in the 5′ Noncoding Region of Sindbis Virus Confers Neurovirulence in Rats

Two pairs of Sindbis virus (SV) variants that differ in their neuroinvasive and neurovirulent traits in mice have been isolated. Recently, we mapped the genetic determinants responsible for neuroinvasiveness in weanling mice. Here, we extend this study to newborn and adult rats and to rat neuronal c...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Kobiler, David, Rice, Charles M., Brodie, Chaya, Shahar, Abraham, Dubuisson, Jean, Halevy, Menahem, Lustig, Shlomo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113099/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10440-10446.1999
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