A Single Nucleotide Change in the 5′ Noncoding Region of Sindbis Virus Confers Neurovirulence in Rats

Two pairs of Sindbis virus (SV) variants that differ in their neuroinvasive and neurovirulent traits in mice have been isolated. Recently, we mapped the genetic determinants responsible for neuroinvasiveness in weanling mice. Here, we extend this study to newborn and adult rats and to rat neuronal c...

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Pubblicato in:	J Virol
Autori principali:	Kobiler, David, Rice, Charles M., Brodie, Chaya, Shahar, Abraham, Dubuisson, Jean, Halevy, Menahem, Lustig, Shlomo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113099/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10440-10446.1999
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