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Attenuation of Sindbis virus neurovirulence by using defined mutations in nontranslated regions of the genome RNA.

We examined a panel of Sindbis virus mutants containing defined mutations in the 5' nontranslated region of the genome RNA, in the 3' nontranslated region, or in both for their growth in cultured cells and virulence in newborn mice. In cultured cells, these viruses all had defects in RNA s...

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Sonraí Bibleagrafaíochta
Main Authors: Kuhn, R J, Griffin, D E, Zhang, H, Niesters, H G, Strauss, J H
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1992
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC240395/
https://ncbi.nlm.nih.gov/pubmed/1433509
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