Attenuation of Sindbis virus neurovirulence by using defined mutations in nontranslated regions of the genome RNA.
We examined a panel of Sindbis virus mutants containing defined mutations in the 5' nontranslated region of the genome RNA, in the 3' nontranslated region, or in both for their growth in cultured cells and virulence in newborn mice. In cultured cells, these viruses all had defects in RNA synthesis a...
Guardat en:
| Publicat a: | J Virol |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1992
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1433509/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.12.7121-7127.1992 |
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