Attenuation of Sindbis virus neurovirulence by using defined mutations in nontranslated regions of the genome RNA.

We examined a panel of Sindbis virus mutants containing defined mutations in the 5' nontranslated region of the genome RNA, in the 3' nontranslated region, or in both for their growth in cultured cells and virulence in newborn mice. In cultured cells, these viruses all had defects in RNA synthesis a...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Kuhn, R J, Griffin, D E, Zhang, H, Niesters, H G, Strauss, J H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC240395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1433509/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.66.12.7121-7127.1992
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