A Single Nucleotide Change in the 5′ Noncoding Region of Sindbis Virus Confers Neurovirulence in Rats

Two pairs of Sindbis virus (SV) variants that differ in their neuroinvasive and neurovirulent traits in mice have been isolated. Recently, we mapped the genetic determinants responsible for neuroinvasiveness in weanling mice. Here, we extend this study to newborn and adult rats and to rat neuronal c...

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Библиографические подробности

Опубликовано в::	J Virol
Главные авторы:	Kobiler, David, Rice, Charles M., Brodie, Chaya, Shahar, Abraham, Dubuisson, Jean, Halevy, Menahem, Lustig, Shlomo
Формат:	Artigo
Язык:	Inglês
Опубликовано:	American Society for Microbiology (ASM) 1999
Предметы:	Pathogenesis and Immunity
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC113099/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10559362/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.12.10440-10446.1999
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