Structure-Based Mutagenesis Study of Hepatitis C Virus NS3 Helicase

The NS3 protein of hepatitis C virus (HCV) is a bifunctional protein containing a serine protease in the N-terminal one-third, which is stimulated upon binding of the NS4A cofactor, and an RNA helicase in the C-terminal two-thirds. In this study, a C-terminal hexahistidine-tagged helicase domain of...

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Bibliographic Details
Main Authors: Lin, Chao, Kim, Joseph L.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112901/
https://ncbi.nlm.nih.gov/pubmed/10482634
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