Structurally Conserved Amino Acid W501 Is Required for RNA Helicase Activity but Is Not Essential for DNA Helicase Activity of Hepatitis C Virus NS3 Protein

Hepatitis C virus (HCV) is a positive-strand RNA virus that encodes a helicase required for viral replication. Although HCV does not replicate through a DNA intermediate, HCV helicase unwinds both RNA and DNA duplexes. An X-ray crystal structure of the HCV helicase complexed with (dU)(8) has been so...

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Detalhes bibliográficos
Main Authors: Kim, Jong Won, Seo, Mi Young, Shelat, Anang, Kim, Chon Saeng, Kwon, Tae Woo, Lu, Hui-hua, Moustakas, Demetri Theodore, Sun, Jeonghoon, Han, Jang H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2003
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC140573/
https://ncbi.nlm.nih.gov/pubmed/12477861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.1.571-582.2003
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