Mutagenesis of the Dengue Virus Type 2 NS3 Protein within and outside Helicase Motifs: Effects on Enzyme Activity and Virus Replication

The protein NS3 of Dengue virus type 2 (DEN-2) is the second largest nonstructural protein specified by the virus and is known to possess multiple enzymatic activities, including a serine proteinase located in the N-terminal region and an NTPase-helicase in the remaining 70% of the protein. The latt...

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Detalhes bibliográficos
Main Authors: Matusan, Anita E., Pryor, Melinda J., Davidson, Andrew D., Wright, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC114534/
https://ncbi.nlm.nih.gov/pubmed/11559795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.20.9633-9643.2001
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