Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase

The carboxyl terminus of the hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses ATP-dependent RNA helicase activity. Based on the conserved sequence motifs and the crystal structures of the helicase domain, 17 mutants of the HCV NS3 helicase were generated. The ATP hydrolysis, RNA bindi...

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Detalhes bibliográficos
Main Authors: Tai, Chun-Ling, Pan, Wen-Ching, Liaw, Shwu-Huey, Yang, Ueng-Cheng, Hwang, Lih-Hwa, Chen, Ding-Shinn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC115073/
https://ncbi.nlm.nih.gov/pubmed/11483774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.17.8289-8297.2001
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