Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase

The carboxyl terminus of the hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses ATP-dependent RNA helicase activity. Based on the conserved sequence motifs and the crystal structures of the helicase domain, 17 mutants of the HCV NS3 helicase were generated. The ATP hydrolysis, RNA bindi...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Tai, Chun-Ling, Pan, Wen-Ching, Liaw, Shwu-Huey, Yang, Ueng-Cheng, Hwang, Lih-Hwa, Chen, Ding-Shinn
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2001
Materias:	Replication
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC115073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11483774/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.75.17.8289-8297.2001
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