Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase

The carboxyl terminus of the hepatitis C virus (HCV) nonstructural protein 3 (NS3) possesses ATP-dependent RNA helicase activity. Based on the conserved sequence motifs and the crystal structures of the helicase domain, 17 mutants of the HCV NS3 helicase were generated. The ATP hydrolysis, RNA bindi...

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Bibliografiske detaljer
Main Authors: Tai, Chun-Ling, Pan, Wen-Ching, Liaw, Shwu-Huey, Yang, Ueng-Cheng, Hwang, Lih-Hwa, Chen, Ding-Shinn
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC115073/
https://ncbi.nlm.nih.gov/pubmed/11483774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.17.8289-8297.2001
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