Herpes Simplex Virus Virion Host Shutoff (vhs) Activity Alters Periocular Disease in Mice

During lytic infection, the virion host shutoff (vhs) protein of herpes simplex virus (HSV) mediates the rapid degradation of RNA and shutoff of host protein synthesis. In mice, HSV type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. HSV-2 has significantly higher vhs activity tha...

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Bibliografische gegevens

Gepubliceerd in:	J Virol
Hoofdauteurs:	Smith, Tracy J., Ackland-Berglund, Cathleen E., Leib, David A.
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology (ASM) 2000
Onderwerpen:	Pathogenesis and Immunity
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111869/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3598-3604.2000
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