Herpes Simplex Virus Virion Host Shutoff (vhs) Activity Alters Periocular Disease in Mice

During lytic infection, the virion host shutoff (vhs) protein of herpes simplex virus (HSV) mediates the rapid degradation of RNA and shutoff of host protein synthesis. In mice, HSV type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. HSV-2 has significantly higher vhs activity tha...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Smith, Tracy J., Ackland-Berglund, Cathleen E., Leib, David A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111869/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3598-3604.2000
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