Deletion of the Virion Host Shutoff Protein (vhs) from Herpes Simplex Virus (HSV) Relieves the Viral Block to Dendritic Cell Activation: Potential of vhs(−) HSV Vectors for Dendritic Cell-Mediated Immunotherapy

Herpes simplex virus (HSV) infects dendritic cells (DC) efficiently but with minimal replication. HSV, therefore, appears to have evolved the ability to enter DC even though they are nonpermissive for virus growth. This provides a potential utility for HSV in delivering genes to DC for vaccination p...

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Autori principali: Samady, Laila, Costigliola, Emanuela, MacCormac, Luci, McGrath, Yvonne, Cleverley, Steve, Lilley, Caroline E., Smith, Jill, Latchman, David S., Chain, Benny, Coffin, Robert S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2003
Soggetti:
Pathogenesis and Immunity
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC149543/
https://ncbi.nlm.nih.gov/pubmed/12610151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.77.6.3768-3776.2003
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