mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease

During lytic infections, the virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral mRNAs. By accelerating the decay of all mRNAs, it helps redirect the cell from host to viral gene expression and facilitates the sequential expression of different classes o...

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Detalles Bibliográficos
Main Authors: Everly, Jr., David N., Feng, Pinghui, Mian, I. Saira, Read, G. Sullivan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2002
Assuntos:
Virus-Cell Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136990/
https://ncbi.nlm.nih.gov/pubmed/12163576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.17.8560-8571.2002
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