mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease

During lytic infections, the virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral mRNAs. By accelerating the decay of all mRNAs, it helps redirect the cell from host to viral gene expression and facilitates the sequential expression of different classes o...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Everly, Jr., David N., Feng, Pinghui, Mian, I. Saira, Read, G. Sullivan
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2002
Fag:	Virus-Cell Interactions
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136990/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12163576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.17.8560-8571.2002
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