mRNA Degradation by the Virion Host Shutoff (Vhs) Protein of Herpes Simplex Virus: Genetic and Biochemical Evidence that Vhs Is a Nuclease

During lytic infections, the virion host shutoff (Vhs) protein (UL41) of herpes simplex virus destabilizes both host and viral mRNAs. By accelerating the decay of all mRNAs, it helps redirect the cell from host to viral gene expression and facilitates the sequential expression of different classes o...

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Pubblicato in:	J Virol
Autori principali:	Everly, Jr., David N., Feng, Pinghui, Mian, I. Saira, Read, G. Sullivan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Virus-Cell Interactions
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136990/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12163576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.76.17.8560-8571.2002
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