Herpes Simplex Virus Virion Host Shutoff (vhs) Activity Alters Periocular Disease in Mice

During lytic infection, the virion host shutoff (vhs) protein of herpes simplex virus (HSV) mediates the rapid degradation of RNA and shutoff of host protein synthesis. In mice, HSV type 1 (HSV-1) mutants lacking vhs activity are profoundly attenuated. HSV-2 has significantly higher vhs activity tha...

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Podrobná bibliografie

Vydáno v:	J Virol
Hlavní autoři:	Smith, Tracy J., Ackland-Berglund, Cathleen E., Leib, David A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Pathogenesis and Immunity
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111869/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10729135/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.8.3598-3604.2000
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