The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

This study assesses the controversial role of the mitochondrial permeability transition (MPT) in apoptosis. In primary rat hepatocytes expressing an IκB superrepressor, tumor necrosis factor alpha (TNFα) induced apoptosis as shown by nuclear morphology, DNA ladder formation, and caspase 3 activation...

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Detalles Bibliográficos
Main Authors: Bradham, Cynthia A., Qian, Ting, Streetz, Konrad, Trautwein, Christian, Brenner, David A., Lemasters, John J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC109221/
https://ncbi.nlm.nih.gov/pubmed/9774651
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