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The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

This study assesses the controversial role of the mitochondrial permeability transition (MPT) in apoptosis. In primary rat hepatocytes expressing an IκB superrepressor, tumor necrosis factor alpha (TNFα) induced apoptosis as shown by nuclear morphology, DNA ladder formation, and caspase 3 activation...

詳細記述

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書誌詳細
主要な著者: Bradham, Cynthia A., Qian, Ting, Streetz, Konrad, Trautwein, Christian, Brenner, David A., Lemasters, John J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC109221/
https://ncbi.nlm.nih.gov/pubmed/9774651
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