The Mitochondrial Permeability Transition Is Required for Tumor Necrosis Factor Alpha-Mediated Apoptosis and Cytochrome c Release

This study assesses the controversial role of the mitochondrial permeability transition (MPT) in apoptosis. In primary rat hepatocytes expressing an IκB superrepressor, tumor necrosis factor alpha (TNFα) induced apoptosis as shown by nuclear morphology, DNA ladder formation, and caspase 3 activation...

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Autores principales: Bradham, Cynthia A., Qian, Ting, Streetz, Konrad, Trautwein, Christian, Brenner, David A., Lemasters, John J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Cell Growth and Development
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC109221/
https://ncbi.nlm.nih.gov/pubmed/9774651
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