Cytochrome c-Dependent Activation of Caspase-3 by Tumor Necrosis Factor Requires Induction of the Mitochondrial Permeability Transition

The killing of L929 mouse fibroblasts by tumor necrosis factor-α (TNF-α) in the presence of 0.5 μg/ml actinomycin D (Act D) is prevented by inhibition of the mitochondrial permeability transition (MPT) with cyclosporin A (CyA) in combination with the phospholipase A(2) inhibitor aristolochic acid (A...

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Autores principales: Tafani, Marco, Schneider, Timothy G., Pastorino, John G., Farber, John L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2000
Materias:
Regular Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1850093/
https://ncbi.nlm.nih.gov/pubmed/10854232
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