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p53 opens the mitochondrial permeability transition pore to trigger necrosis
Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss in human health. Elucidating its signaling mechanism is of paramount importance. p53 is a central stress sensor responding to multiple insults including oxidative stress to orchestrate apoptotic and...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3383624/ https://ncbi.nlm.nih.gov/pubmed/22726440 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.014 |
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