Werner’s syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

Individuals affected by the autosomal recessive disorder Werner’s syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a reduced replicative life span. The WRN gene encodes a 3′–5′ DNA helica...

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Main Authors: Constantinou, Angelos, Tarsounas, Madalena, Karow, Julia K., Brosh, Robert M., Bohr, Vilhelm A., Hickson, Ian D., West, Stephen C.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2000
主題:
Scientific Reports
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083680/
https://ncbi.nlm.nih.gov/pubmed/11256630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd004
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