Werner’s syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

Individuals affected by the autosomal recessive disorder Werner’s syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a reduced replicative life span. The WRN gene encodes a 3′–5′ DNA helica...

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Detalhes bibliográficos
Main Authors: Constantinou, Angelos, Tarsounas, Madalena, Karow, Julia K., Brosh, Robert M., Bohr, Vilhelm A., Hickson, Ian D., West, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083680/
https://ncbi.nlm.nih.gov/pubmed/11256630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd004
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