Werner’s syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

Individuals affected by the autosomal recessive disorder Werner’s syndrome (WS) develop many of the symptoms characteristic of premature ageing. Primary fibroblasts cultured from WS patients exhibit karyotypic abnormalities and a reduced replicative life span. The WRN gene encodes a 3′–5′ DNA helica...

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Bibliographic Details
Main Authors: Constantinou, Angelos, Tarsounas, Madalena, Karow, Julia K., Brosh, Robert M., Bohr, Vilhelm A., Hickson, Ian D., West, Stephen C.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083680/
https://ncbi.nlm.nih.gov/pubmed/11256630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd004
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