Transmission Barriers for Bovine, Ovine, and Human Prions in Transgenic Mice

Transgenic (Tg) mice expressing full-length bovine prion protein (BoPrP) serially propagate bovine spongiform encephalopathy (BSE) prions without posing a transmission barrier. These mice also posed no transmission barrier for Suffolk sheep scrapie prions, suggesting that cattle may be highly suscep...

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Bibliografske podrobnosti
Main Authors: Scott, Michael R., Peretz, David, Nguyen, Hoang-Oanh B., DeArmond, Stephen J., Prusiner, Stanley B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2005
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1082721/
https://ncbi.nlm.nih.gov/pubmed/15827140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.9.5259-5271.2005
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