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PI3K integrates the action of insulin and leptin on hypothalamic neurons

Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral energy stores. Leptin and insulin have been implicated as circulating indicators of adiposity, but it is not clea...

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Detalhes bibliográficos
Main Authors: Xu, Allison Wanting, Kaelin, Christopher B., Takeda, Kiyoshi, Akira, Shizuo, Schwartz, Michael W., Barsh, Gregory S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1062894/
https://ncbi.nlm.nih.gov/pubmed/15761497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200524301
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