Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

Normal food intake and body weight homeostasis require the direct action of leptin on hypothalamic proopiomelanocortin (POMC) neurons. It has been proposed that leptin action requires PI3K activity. We therefore assessed the contribution of PI3K signaling to leptin’s effects on POMC neurons and orga...

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Detalhes bibliográficos
Main Authors: Hill, Jennifer W., Williams, Kevin W., Ye, Chianping, Luo, Ji, Balthasar, Nina, Coppari, Roberto, Cowley, Michael A., Cantley, Lewis C., Lowell, Bradford B., Elmquist, Joel K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2276395/
https://ncbi.nlm.nih.gov/pubmed/18382766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32964
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