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PI3K integrates the action of insulin and leptin on hypothalamic neurons

Central control of energy balance depends on the ability of proopiomelanocortin (POMC) or agouti-related protein (Agrp) hypothalamic neurons to sense and respond to changes in peripheral energy stores. Leptin and insulin have been implicated as circulating indicators of adiposity, but it is not clea...

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Autori principali: Xu, Allison Wanting, Kaelin, Christopher B., Takeda, Kiyoshi, Akira, Shizuo, Schwartz, Michael W., Barsh, Gregory S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1062894/
https://ncbi.nlm.nih.gov/pubmed/15761497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200524301
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