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Mode of Action of (1′S,2′R)-9-{[1′,2′-Bis(hydroxymethyl) cycloprop-1′-yl]methyl}guanine (A-5021) against Herpes Simplex Virus Type 1 and Type 2 and Varicella-Zoster Virus

The mode of action of (1′S,2′R)-9-{[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine (A-5021) against herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV) was studied. A-5021 was monophosphorylated at the 2′ site by viral thymidine kinases (TKs). The 50% inhibitory valu...

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Main Authors: Ono, Nobukazu, Iwayama, Satoshi, Suzuki, Katsuya, Sekiyama, Takaaki, Nakazawa, Harumi, Tsuji, Takashi, Okunishi, Masahiko, Daikoku, Tohru, Nishiyama, Yukihiro
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 1998
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC105870/
https://ncbi.nlm.nih.gov/pubmed/9687413
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