Antiherpesvirus Activities of (1′S,2′R)-9-{[1′,2′-Bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine (A-5021) in Cell Culture

Antiherpetic activity of (1′S,2′R)-9-{[1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine (A-5021) was compared with those of acyclovir (ACV) and penciclovir (PCV) in cell cultures. In a plaque reduction assay using a selection of human cells, A-5021 showed the most potent activity in all cells....

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Iwayama, Satoshi, Ono, Nobukazu, Ohmura, Yuko, Suzuki, Katsuya, Aoki, Miho, Nakazawa, Harumi, Oikawa, Miki, Kato, Tamamo, Okunishi, Masahiko, Nishiyama, Yukihiro, Yamanishi, Koichi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105663/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1666
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