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p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
Four molecules of the tumor suppressor p53 assemble to cooperatively bind proapoptotic target genes. The structural basis for cooperativity consists of interactions between adjacent DNA binding domains. Mutations at the interaction interface that compromise cooperativity were identified in cancer pa...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2013-05-01
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| Colecção: | Cell Reports |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2211124713001757 |
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