Characterization of the p53 Cistrome – DNA Binding Cooperativity Dissects p53's Tumor Suppressor Functions

p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells. How p53 selects target genes in the genome in a context- and tissue-specific manner remains largely obscure. There is growing evid...

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Autors principals: Schlereth, Katharina, Heyl, Charlotte, Krampitz, Anna-Maria, Mernberger, Marco, Finkernagel, Florian, Scharfe, Maren, Jarek, Michael, Leich, Ellen, Rosenwald, Andreas, Stiewe, Thorsten
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3744428/
https://ncbi.nlm.nih.gov/pubmed/23966881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003726
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