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The Golgi as a “Proton Sink” in Cancer

Cancer cells exhibit increased glycolytic flux and adenosine triphosphate (ATP) hydrolysis. These processes increase the acidic burden on the cells through the production of lactate and protons. Nonetheless, cancer cells can maintain an alkaline intracellular pH (pHi) relative to untransformed cells...

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Bibliografiske detaljer
Principais autores: Koen M. O. Galenkamp, Cosimo Commisso
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-05-01
Serier:Frontiers in Cell and Developmental Biology
Fag:
Online adgang:https://www.frontiersin.org/articles/10.3389/fcell.2021.664295/full
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