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In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories

Toxicokinetic (TK) assays and in vitro–in vivo extrapolation (IVIVE) models are New Approach Methods (NAMs) used to translate in vitro points of departure to exposure estimates required to reach equivalent blood concentrations. Per- and polyfluoroalkyl substances (PFAS) are a large chemical class wi...

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Sparad:
Huvudupphov: David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore
Materialtyp: Artigo
Språk:Inglês
Utgiven: MDPI AG 2024-09-01
Serie:Toxics
Ämnen:
PFAS
toxicokinetics (TK)
hepatic clearance
in vitro–in vivo extrapolation (IVIVE)
New Approach Methods (NAMs)
metabolism
Länkar:https://www.mdpi.com/2305-6304/12/9/672
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