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In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories

Toxicokinetic (TK) assays and in vitro–in vivo extrapolation (IVIVE) models are New Approach Methods (NAMs) used to translate in vitro points of departure to exposure estimates required to reach equivalent blood concentrations. Per- and polyfluoroalkyl substances (PFAS) are a large chemical class wi...

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Principais autores: David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2024-09-01
סדרה:Toxics
נושאים:
PFAS
toxicokinetics (TK)
hepatic clearance
in vitro–in vivo extrapolation (IVIVE)
New Approach Methods (NAMs)
metabolism
גישה מקוונת:https://www.mdpi.com/2305-6304/12/9/672
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