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In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories

Toxicokinetic (TK) assays and in vitro–in vivo extrapolation (IVIVE) models are New Approach Methods (NAMs) used to translate in vitro points of departure to exposure estimates required to reach equivalent blood concentrations. Per- and polyfluoroalkyl substances (PFAS) are a large chemical class wi...

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Principais autores: David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-09-01
Serier:Toxics
Fag:
PFAS
toxicokinetics (TK)
hepatic clearance
in vitro–in vivo extrapolation (IVIVE)
New Approach Methods (NAMs)
metabolism
Online adgang:https://www.mdpi.com/2305-6304/12/9/672
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