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In Vitro Hepatic Clearance Evaluations of Per- and Polyfluoroalkyl Substances (PFAS) across Multiple Structural Categories

Toxicokinetic (TK) assays and in vitro–in vivo extrapolation (IVIVE) models are New Approach Methods (NAMs) used to translate in vitro points of departure to exposure estimates required to reach equivalent blood concentrations. Per- and polyfluoroalkyl substances (PFAS) are a large chemical class wi...

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Main Authors: David M. Crizer, Julie R. Rice, Marci G. Smeltz, Katelyn S. Lavrich, Krishna Ravindra, John F. Wambaugh, Michael DeVito, Barbara A. Wetmore
Format: Artigo
Language:Inglês
Published: MDPI AG 2024-09-01
Series:Toxics
Subjects:
PFAS
toxicokinetics (TK)
hepatic clearance
in vitro–in vivo extrapolation (IVIVE)
New Approach Methods (NAMs)
metabolism
Online Access:https://www.mdpi.com/2305-6304/12/9/672
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