Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

Abstract Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide association studies. Recognizing that linkage...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-04-01
Edice:	BMC Research Notes
Témata:	Methylation scores Schizophrenia Methylome-wide association studies Summary statistics LDpred2 Polygenic risk score
On-line přístup:	https://doi.org/10.1186/s13104-025-07222-2
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!