Can polygenic risk scores help explain disease prevalence differences around the world? A worldwide investigation

Abstract Complex disorders are caused by a combination of genetic, environmental and lifestyle factors, and their prevalence can vary greatly across different populations. The extent to which genetic risk, as identified by Genome Wide Association Study (GWAS), correlates to disease prevalence in dif...

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Hlavní autoři:	Pritesh R. Jain, Myson Burch, Melanie Martinez, Pablo Mir, Jakub P. Fichna, Cezary Zekanowski, Renata Rizzo, Zeynep Tümer, Csaba Barta, Evangelia Yannaki, John Stamatoyannopoulos, Petros Drineas, Peristera Paschou
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-11-01
Edice:	BMC Genomic Data
Témata:	GWAS PRS Polygenic risk score Ancestry Disease prevalence
On-line přístup:	https://doi.org/10.1186/s12863-023-01168-9
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