Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

Abstract Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide association studies. Recognizing that linkage...

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Autori principali:	Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-04-01
Serie:	BMC Research Notes
Soggetti:	Methylation scores Schizophrenia Methylome-wide association studies Summary statistics LDpred2 Polygenic risk score
Accesso online:	https://doi.org/10.1186/s13104-025-07222-2
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