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Using LDpred2 to adapt polygenic risk score techniques for methylation score creation

Abstract Objective This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide association studies. Recognizing that linkage...

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Wedi'i Gadw mewn:
Prif Awduron: Kristoffer Sandås, Leticia Spindola, Solveig Løkhammer, Anne-Kristin Stavrum, Ole Andreassen, Markos Tesfaye, Stéphanie Le Hellard
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2025-04-01
Cyfres:BMC Research Notes
Pynciau:
Methylation scores
Schizophrenia
Methylome-wide association studies
Summary statistics
LDpred2
Polygenic risk score
Mynediad Ar-lein:https://doi.org/10.1186/s13104-025-07222-2
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