From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome

Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent aneuploidy observed in the human population and represents the most common genetic form of intellectual disability and early-onset Alzheimer’s disease (AD). Individuals with DS exhibit a wide spectrum of clinical prese...

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Principais autores:	L. Ashley Watson, Hiruy S. Meharena
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2023-05-01
Series:	Frontiers in Genetics
Assuntos:	down syndrome neurodevelomental disorders neurodegenenerative diseases human tissue cell culture models human stem cells
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1198129/full
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