From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome

Down syndrome (DS), caused by triplication of chromosome 21, is the most frequent aneuploidy observed in the human population and represents the most common genetic form of intellectual disability and early-onset Alzheimer’s disease (AD). Individuals with DS exhibit a wide spectrum of clinical prese...

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Hlavní autoři:	L. Ashley Watson, Hiruy S. Meharena
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-05-01
Edice:	Frontiers in Genetics
Témata:	down syndrome neurodevelomental disorders neurodegenenerative diseases human tissue cell culture models human stem cells
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fgene.2023.1198129/full
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